4-Bromo(~2~H_4_)benzoic acid(CAS: 787624-24-2)

4-Bromo(2H-4-)benzoic acid is a white crystalline solid with a molecular weight of approximately 211.03 g/mol. It has a pKa of about 4.25 and is slightly soluble in water (0.16 g/100 mL at 20°C). The compound is reactive towards bases and can undergo substitution reactions. It is also sensitive to light and air oxidation.

4-Bromo(2H-4-)benzoic acid is typically synthesized by bromination of benzoic acid with bromine in the presence of a base such as sodium hydroxide. The reaction is carried out in a water/solvent mixture like water/methanol. The yield is around 70-80%, and the product is purified by recrystallization from an appropriate solvent.

4-Bromo(2H-4-)benzoic acid is primarily used in the pharmaceutical industry for the synthesis of intermediates and drug candidates. It also finds applications in the polymer industry as a stabilizer and in the development of sensors and semiconductors due to its chemical reactivity and stability.

When handling 4-Bromo(2H-4-)benzoic acid, wear appropriate personal protective equipment (PPE) including safety goggles, gloves, and a lab coat. Work in a fume hood to avoid inhalation of vapors. Store the compound in a cool, dry place away from direct sunlight. In case of a spill, contain it with appropriate absorbent material and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.