methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate(CAS: 50370-56-4)

Methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate has a crystalline form with a molecular weight of approximately 304.21 g/mol. It is slightly soluble in water but soluble in organic solvents. This compound is reactive towards nucleophiles and acidic conditions. It has a pKa of approximately 2.5.

Methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate is typically synthesized through a multistep process involving condensation reactions, cyclization, and esterification. The synthesis can involve the use of catalysts such as p-toluenesulfonic acid and can yield up to 90% purity with good selectivity.

Methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate is mainly used in the pharmaceutical industry for the development of certain drugs and in the chemical industry for its use as a precursor in organic synthesis. It can also find applications in polymer chemistry and as a reagent in analytical chemistry.

When handling methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a laboratory coat. It should be stored in a cool, dry place, away from direct sunlight and heat sources. Spills should be handled with care, and the Material Safety Data Sheet (MSDS) should be consulted for specific emergency procedures.