1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(CAS: 94695-52-0)

1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is typically available as a white crystalline powder with a molecular weight of approximately 313.09 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, showing limited reactivity towards basic conditions. It is stable under normal storage conditions but should be protected from strong oxidizing agents and moisture.

1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is synthesized via a multistep process involving the alkylation of 6,7,8-trifluoroquinoline with cyclopropyl chloride, followed by subsequent reactions to introduce the oxo and carboxylic acid functionalities. Common methods include the use of triethylamine as a base and chlorotriphenylphosphine as a catalyst. The overall yield can range from 50% to 70%, depending on the purity of starting materials and reaction conditions.

1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is primarily used in the pharmaceutical industry as a building block for drug synthesis. It can also find applications in the production of organic semiconductors and sensors due to its electronic and chemical properties. While less common, it may occasionally be used in polymer chemistry for specific functionalization purposes.

When handling 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.