5-Methoxy-1H-benzotriazole(CAS: 27799-91-3)

5-Methoxy-1H-benzotriazole is a white crystalline solid with a molecular weight of approximately 218.21 g/mol. It has a high solubility in organic solvents like DMF and DMSO but limited solubility in water. Chemically, it is stable but can undergo hydrolysis in basic media. It is used as a UV absorber and photostabilizer in various applications.

5-Methoxy-1H-benzotriazole is commonly synthesized via the reaction of 1,4-benzotriazol-1-ylium tosylate with methanol. The process involves the deprotonation of 1,4-benzotriazol-1-yl tosylate with a strong base like sodium hydride, followed by the addition of methanol. The reaction yields a methoxy-protected benzotriazole with high selectivity and good yield.

5-Methoxy-1H-benzotriazole is widely used in the pharmaceutical industry as a photoprotective agent in drug formulations. It is also utilized in the polymer industry for UV stabilization, in the semiconductor industry as a precursor for photolithography, and in sensor technology for its photochemical properties.

When handling 5-Methoxy-1H-benzotriazole, it is essential to wear appropriate personal protective equipment (PPE), including gloves and goggles. Ensure the work is conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using an appropriate absorbent material followed by thorough cleaning with water and detergent. Always consult the safety data sheet (SDS) for detailed handling and emergency procedures.