2-Bromo-5-iodobenzaldehyde(CAS: 1032231-24-5)

2-Bromo-5-iodobenzaldehyde is a white crystalline solid with a molecular weight of approximately 352.1 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. This compound is known for its high reactivity, particularly towards nucleophilic substitution reactions and condensation reactions. It is often used in organic synthesis due to its unique bromo-iodo substituents.

2-Bromo-5-iodobenzaldehyde can be synthesized via the coupling of 2-bromobenzaldehyde with iodobenzene in the presence of a suitable catalyst such as potassium carbonate. The reaction is carried out in an aprotic solvent like dimethylformamide (DMF) at elevated temperatures. The yield is typically high, and the product is isolated by recrystallization from a suitable solvent.

2-Bromo-5-iodobenzaldehyde is primarily used in the pharmaceutical industry for the synthesis of complex organic compounds. It also finds applications in the polymer industry for the modification of polymer properties and in the semiconductor industry for the preparation of functional materials. Its unique chemical properties make it valuable in various sensor technologies for detecting specific chemicals or gases.

When handling 2-Bromo-5-iodobenzaldehyde, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. In case of a spill, immediately clean up using absorbent material and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.