Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate(CAS: 179688-26-7)

Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate is a crystalline compound with a molecular weight of approximately 420.42 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is highly reactive towards nucleophiles and is prone to nitro group reduction under basic conditions. It is stable under normal storage conditions but should be protected from moisture and light.

Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate is typically synthesized via nitration of 4,5-bis(2-methoxyethoxy)-2-nitrobenzoic acid using concentrated nitric acid. This process requires careful control of temperature and concentration to achieve high yield and selectivity. The reaction is usually carried out in a solvent like acetic acid or toluene, with the product isolated by crystallization.

Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate is used in the pharmaceutical industry as an intermediate for the synthesis of certain drugs, particularly those requiring nitro functionality. It is also utilized in the polymer industry for its reactive properties and in the semiconductor industry for its use as a precursor in organic thin-film transistors.

When handling Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. This compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. SDS (Safety Data Sheet) should be consulted for detailed emergency response procedures and storage recommendations.