cis-3,3a,6,6a-tetrahydrocyclopenta[b]furan-2-one(CAS: 26054-46-6)

cis-3,3a,6,6a-Tetrahydrocyclopenta[b]furan-2-one is a colorless crystalline solid with a molecular weight of approximately 150.24 g/mol. It has a low solubility in water but is soluble in common organic solvents like ethanol and acetone. The compound is relatively stable under normal conditions but can react with strong bases or acids. It shows moderate reactivity in electrophilic addition reactions.

cis-3,3a,6,6a-Tetrahydrocyclopenta[b]furan-2-one can be synthesized via the Wittig reaction, where an aldehyde reacts with a phosphoryl donor to form the desired ketone. Another method involves the Diels-Alder reaction between a diene and a dienophile. These methods provide high selectivity and yield, with optimization of reaction conditions leading to better outcomes.

cis-3,3a,6,6a-Tetrahydrocyclopenta[b]furan-2-one finds applications in the pharmaceutical industry for its use as an intermediate in drug synthesis. It is also utilized in the polymer industry for the development of new materials. Additionally, it is employed in the production of sensors and as a precursor in the semiconductor industry for manufacturing electronic components.

cis-3,3a,6,6a-Tetrahydrocyclopenta[b]furan-2-one should be handled in a well-ventilated area and under a fume hood. Use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Ensure the area is equipped with an eye wash station and a spill kit. Follow standard laboratory safety protocols, and consult the Safety Data Sheet (SDS) for specific handling and disposal instructions.