3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one(CAS: 603-61-2)

3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one is a white crystalline powder with a molecular weight of approximately 390.42 g/mol. It is slightly soluble in water and ethanol. The compound exhibits moderate reactivity towards acidic and basic conditions, with potential for hydrolysis and condensation reactions. It has a melting point of around 305-307°C and a boiling point of approximately 500-520°C under reduced pressure.

3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one is typically synthesized through a condensation reaction between 3-hydroxy-4-methoxybenzaldehyde and 2-hydroxycoumarin in the presence of catalytic amounts of phosphoric acid. The reaction proceeds with high selectivity and yields up to 90% of the target compound under mild conditions.

3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It also finds applications in the production of certain pigments and dyes. Additionally, it may be used in the development of sensors and semiconductors due to its unique optical and electronic properties.

When handling 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one, it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly washed down. Always refer to the safety data sheet (SDS) for specific handling and disposal instructions.