4-(pyridin-4-yloxy)aniline(CAS: 102877-78-1)

4-(Pyridin-4-yloxy)aniline (CAS: 102877-78-1) is a crystalline solid with a molecular weight of approximately 205.17 g/mol. It has a high solubility in polar solvents like methanol and ethanol but is sparingly soluble in water. The compound exhibits moderate reactivity towards nucleophiles and electrophiles, making it useful in various synthetic transformations. It does not readily undergo thermal decomposition under normal conditions.

4-(Pyridin-4-yloxy)aniline (CAS: 102877-78-1) can be synthesized via the condensation of 4-hydroxyaniline with 4-bromopyridine in the presence of a base such as potassium carbonate. This process requires a mild temperature and is carried out in an aqueous medium. The yield is typically around 75-85%, depending on the purity of the starting materials and reaction conditions.

4-(Pyridin-4-yloxy)aniline (CAS: 102877-78-1) is used in the pharmaceutical industry for the synthesis of certain drug candidates, particularly those involving pyridine derivatives. It also finds application in the polymer industry as a precursor for various polymers and in the semiconductor industry for organic electronic materials. Additionally, it is utilized in the development of chemical sensors due to its unique reactivity and stability.

When handling 4-(pyridin-4-yloxy)aniline (CAS: 102877-78-1), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be cleaned up immediately using personal protective equipment and following standard laboratory procedures. Always refer to the safety data sheet (SDS) for detailed handling and disposal information.