N-[(2Z)-3-Benzyl-4-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide(CAS: 2687970-96-1)

N-[(2Z)-3-Benzyl-4-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide is a crystalline solid with a molecular weight of approximately 471.45 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and acetonitrile. This compound is reactive towards nucleophiles and can undergo hydrolysis under basic conditions. It exhibits good stability under neutral and acidic conditions.

N-[(2Z)-3-Benzyl-4-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide can be synthesized by a multi-step process involving the condensation of an appropriate thiazole and pyrrole derivative. Typically, this involves the use of a catalyst such as a Lewis acid, and the reaction is carried out in an organic solvent. The yield is usually moderate to good, and the product can be purified by column chromatography or recrystallization.

N-[(2Z)-3-Benzyl-4-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide finds applications in the pharmaceutical and materials industries. It can be used as a precursor in the development of new drugs and as a functional group in the synthesis of advanced polymers and sensors. Its use in semiconductors is currently less common but could be explored for specific applications.

When handling N-[(2Z)-3-Benzyl-4-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handling should be done in a well-ventilated area or a fume hood to avoid exposure to vapors. Spills should be cleaned up using appropriate absorbent materials and the area should be properly ventilated. Safety data sheets (SDS) should be consulted for detailed handling and disposal procedures.