4,6-Bis(difluoromethoxy)-2-pyrimidinamine(CAS: 86209-44-1)

4,6-Bis(difluoromethoxy)-2-pyrimidinamine (CAS: 86209-44-1) has a crystalline form with a molecular weight of 306.08 g/mol. It is slightly soluble in water and is highly soluble in organic solvents like DMSO and DMF. This compound is moderately reactive, showing certain reactivity towards nucleophiles and bases. It has a low vapor pressure and is stable under normal conditions.

4,6-Bis(difluoromethoxy)-2-pyrimidinamine (CAS: 86209-44-1) is typically synthesized via a multistep process involving the protection of a pyrimidine ring with methoxy groups followed by the introduction of difluoromethoxy groups. Commonly used catalysts include triphenylphosphine and various metal complexes. The overall yield ranges from 60% to 80%, with high selectivity towards the desired product.

4,6-Bis(difluoromethoxy)-2-pyrimidinamine (CAS: 86209-44-1) is primarily used in the pharmaceutical industry for the development of new drugs. It is also utilized in the polymer industry for the synthesis of advanced polymers and in the sensor industry for detecting specific chemical species. Additionally, its use in semiconductor manufacturing for specific applications is increasing.

When handling 4,6-Bis(difluoromethoxy)-2-pyrimidinamine (CAS: 86209-44-1), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and laboratory coats. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed handling and disposal procedures. It is also important to ensure proper storage in a secure, cool, and dry location away from incompatible materials.