2-Fluoro-4-methylaniline(CAS: 452-80-2)

2-Fluoro-4-methylaniline is a colorless to light yellow crystalline solid with a molecular weight of approximately 147.05 g/mol. It has a solubility of about 5.6 g/L in water. This compound is known for its reactivity, particularly towards nucleophilic substitution and electrophilic aromatic substitution reactions.

2-Fluoro-4-methylaniline is synthesized via the nitration of 4-methylaniline followed by reduction of the resulting 4-fluoro-N-methylaniline nitro compound. This process often involves the use of sulfuric acid as a catalyst and requires careful control of temperature and reagent quantities to achieve high yield and selectivity.

2-Fluoro-4-methylaniline finds applications in pharmaceuticals, where it is used as an intermediate in the synthesis of drugs. It is also utilized in the production of dyes and pigments, and in the development of sensor technologies due to its unique chemical properties.

When handling 2-Fluoro-4-methylaniline, it is essential to use proper personal protective equipment (PPE) such as gloves and safety goggles. This compound should be stored in a cool, dry, and well-ventilated area, and handled in a fume hood to minimize inhalation risk. In case of spillage, avoid direct contact and clean up using appropriate chemical spill kits. Always refer to the Safety Data Sheet (SDS) for detailed safety instructions.