1-(4-Pyridinyl)-4-piperidinone(CAS: 126832-81-3)

1-(4-Pyridinyl)-4-piperidinone is a crystalline solid with a molecular weight of approximately 234.24 g/mol. It has a solubility of 10.3 mg/mL in water. Chemically, it is a weak base and exhibits limited reactivity, primarily undergoing hydrolysis and condensation reactions. This compound is stable under normal storage conditions but should be protected from moisture to prevent hydrolysis.

1-(4-Pyridinyl)-4-piperidinone is synthesized via the condensation of 4-piperidone and 4-pyridylamine. Commonly, this is achieved by reacting piperidone with 4-pyridylamine in the presence of a base such as triethylamine. The reaction is typically carried out in an aprotic solvent like dimethylformamide (DMF) at room temperature. The yield is around 85%, with good selectivity towards the desired product.

1-(4-Pyridinyl)-4-piperidinone finds applications in various industries. It is used as a precursor in pharmaceuticals for synthesizing drugs, in the polymer industry for developing new materials, and in sensors due to its unique chemical properties. Additionally, it is used in the semiconductor industry for its ability to act as a photoresist material.

When handling 1-(4-Pyridinyl)-4-piperidinone, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be stored in a dry, sealed container to prevent hydrolysis. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.