5-(hydroxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione(CAS: 4433-40-3)

5-(hydroxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione is a crystalline compound with a molecular weight of approximately 190.17 g/mol. It has a high solubility in water and poor solubility in organic solvents. The compound is known for its reactivity, particularly in nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

5-(hydroxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione is typically synthesized through the condensation of 2,4-dione and 5-hydroxymethyl-1,2,3,4-tetrahydropyrimidine. Commonly, this involves the use of a base like sodium hydroxide to facilitate the reaction. The yield is generally high, and the reaction is selective for the desired product under mild conditions.

5-(hydroxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione finds applications in the pharmaceutical industry for its use as a precursor in the synthesis of drugs. It is also utilized in the polymer industry for the development of new materials. Additionally, it has potential uses in sensors and semiconductors due to its unique chemical properties.

When handling 5-(hydroxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place and handled in a fume hood. In case of a spill, it is recommended to sweep the substance into a container and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.