2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide hydrochloride (1:1)(CAS: 613677-28-4)

2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide hydrochloride is a crystalline solid with a molecular weight of approximately 443.76 g/mol. It has a pKa of around 1.5 and is soluble in water and organic solvents. The compound exhibits good stability under normal conditions but can react with strong bases. It is typically found in a form that is stable under acidic conditions.

2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide hydrochloride is typically synthesized through a multi-step process involving amidation and hydrochlorylation reactions. Key steps include the reaction of 2,4,6-trifluorobenzoyl chloride with 6-(1-methyl-4-piperidinyl)isonicotinoyl chloride in the presence of a suitable base, followed by hydrochlorylation to form the hydrochloride salt. The reaction yields are generally good, with selectivity towards the desired product.

2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide hydrochloride is primarily used in the pharmaceutical industry for its potential as a drug candidate. It is also of interest in sensor technology due to its chemical reactivity and selectivity. Additionally, it may have applications in the semiconductor industry for its electronic properties.

When handling 2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide hydrochloride, it is important to wear appropriate personal protective equipment, including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate methods, and safety data sheets (SDS) should be consulted for detailed handling instructions.