4-Hydroxy-1-isoindolinone(CAS: 366453-21-6)

4-Hydroxy-1-isoindolinone is a white to off-white crystalline solid with a molecular weight of approximately 170.19 g/mol. Its solubility in water is low, around 0.23 g/L at 25°C. The compound is relatively stable but can undergo slow hydrolysis under basic conditions. It is an electrophilic aromatic compound, making it reactive towards nucleophiles.

4-Hydroxy-1-isoindolinone is typically synthesized through a condensation reaction between acetophenone and urea, followed by hydrolysis. This process is catalyzed by a strong base like sodium hydroxide. The yield is usually around 70-80%, and the reaction is performed under mild conditions to ensure selectivity.

4-Hydroxy-1-isoindolinone is used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It is also utilized in the polymer industry for the production of certain types of plastics and in the chemical sensor industry for developing gas sensors. Additionally, it has applications in the semiconductor industry for the production of photoresists.

When handling 4-Hydroxy-1-isoindolinone, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures.