1-(Tetrahydro-2H-pyran-2-YL)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-1H-imidazole(CAS: 1029684-37-4)

The compound is a solid with a crystalline form. Its molecular weight is approximately 416.46 g/mol. It has low water solubility but good solubility in organic solvents such as methanol and acetonitrile. Chemically, it shows reactivity similar to imidazoles, particularly with nucleophiles and electrophiles. It exhibits good stability under normal conditions but can react with strong acids or bases.

The compound is synthesized using a Suzuki coupling reaction. Typically, 1-(tetrahydro-2H-pyran-2-yl)-imidazole is reacted with 4,4,5,5-tetramethyl-2-borono-1,3,2-dioxaborole in the presence of a palladium catalyst, such as Pd(PPh3)2Cl2, and a base like cesium carbonate. The reaction yields the target compound with high selectivity and good yield.

This compound is used in the pharmaceutical industry for its potential as a drug candidate due to its unique structure. It is also utilized in the polymer industry for its ability to enhance the properties of certain polymers. Additionally, it finds applications in sensor technology and semiconductor manufacturing, where it can be used in the synthesis of functional materials.

When handling this compound, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be handled carefully, using appropriate absorbents and disposing of the waste according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.