4-Bromo-5-phenyl-1H-pyrazole(CAS: 13808-65-6)

4-Bromo-5-phenyl-1H-pyrazole is a white to off-white crystalline solid with a molecular weight of approximately 238.05 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and methanol. Chemically, it is reactive towards nucleophiles and is stable in neutral to slightly acidic conditions.

4-Bromo-5-phenyl-1H-pyrazole is commonly synthesized via a multistep process involving bromination of 5-phenyl-1H-pyrazole followed by subsequent reactions. The synthesis often uses reagents like N-bromosuccinimide (NBS) and azobisisobutyronitrile (AIBN) as catalysts. The yield can be improved by optimizing reaction conditions and using appropriate solvents.

4-Bromo-5-phenyl-1H-pyrazole is used in various industries, particularly in pharmaceuticals for its potential as an intermediate in drug synthesis. It also finds applications in polymer chemistry, where it can be used as a monomer or additive. Additionally, it is employed in the development of sensors and semiconductors due to its unique chemical properties.

When handling 4-Bromo-5-phenyl-1H-pyrazole, it is crucial to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. In case of a spill, avoid contact with skin and eyes; clean up using appropriate chemical spill kits. Always consult the safety data sheet (SDS) for detailed information on handling and disposal.