(5-Bromo-3-pyridinyl)boronic acid(CAS: 452972-09-7)

(5-Bromo-3-pyridinyl)boronic acid (CAS: 452972-09-7) is a solid crystalline compound with a molecular weight of approximately 268.06 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and acetonitrile. This compound is known for its reactivity in boronate ester formation and is used in various organic synthesis reactions. It exhibits good stability under standard storage conditions but can react with strong acids or bases.

(5-Bromo-3-pyridinyl)boronic acid (CAS: 452972-09-7) can be synthesized through a variety of methods, including the protective group approach using bromopyridine followed by borolysis. Another common method involves the direct bromination of pyridine followed by boronation. These processes typically require mild to moderate reaction conditions and can achieve yields ranging from 50% to 80%, depending on the specific method used and the purity of the starting materials.

(5-Bromo-3-pyridinyl)boronic acid (CAS: 452972-09-7) is widely used in pharmaceuticals for the synthesis of drug intermediates, in polymer science for the modification of polymer chains, and in sensor technology for the development of biosensors. It is also utilized in semiconductor production for the fabrication of electronic devices due to its unique chemical properties.

When handling (5-Bromo-3-pyridinyl)boronic acid (CAS: 452972-09-7), it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats. This compound should be handled in a well-ventilated area or a fume hood to prevent inhalation of dust or vapors. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly washed down with water. Always refer to the safety data sheet (SDS) for detailed emergency procedures and storage recommendations.