Methyl 6-chloro-3-pyridazinecarboxylate(CAS: 65202-50-8)

Methyl 6-chloro-3-pyridazinecarboxylate (CAS: 65202-50-8) is a crystalline solid with a molecular weight of approximately 229.64 g/mol. It is slightly soluble in water and more soluble in organic solvents such as ethanol and acetone. This compound is reactive towards nucleophiles and can undergo nucleophilic substitution reactions. It has a pKa of about 4.5, indicating a weak carboxylic acid functionality.

Methyl 6-chloro-3-pyridazinecarboxylate (CAS: 65202-50-8) is typically synthesized via the reaction of 3-pyridazinecarboxylic acid with methyl chloroformate in the presence of a base like sodium hydroxide. The reaction is carried out in an aprotic solvent such as dimethylformamide (DMF). The yield is generally around 85-90%, and the reaction is highly selective due to the nucleophilic nature of the amide group.

Methyl 6-chloro-3-pyridazinecarboxylate (CAS: 65202-50-8) is primarily used in the pharmaceutical industry as a precursor in the synthesis of certain drugs. It is also utilized in the sensor and semiconductor industries for its electronic properties. In polymers, it can be used as a stabilizer or additive.

When handling methyl 6-chloro-3-pyridazinecarboxylate (CAS: 65202-50-8), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated fume hood to avoid inhalation of vapors. Spills should be cleaned up using appropriate absorbent materials and properly disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for specific safety guidelines.