2-Butoxyphenylboronic acid(CAS: 91129-69-0)

2-Butoxyphenylboronic acid is a white crystalline solid with a molecular weight of approximately 201.23 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. It exhibits good reactivity in boronate ester formations and is often used in Suzuki coupling reactions. The compound is stable under normal conditions but should be stored in a cool, dry environment to prevent hydrolysis.

2-Butoxyphenylboronic acid is typically synthesized via the boronic acid pinacol ester method. The process involves the reaction of 2-butoxyphenol with boron tribromide in the presence of a base. The reaction yields a mixture of isomers, and purification is usually achieved through column chromatography. The yield is around 85%, and the reaction is carried out under anhydrous conditions to ensure high purity.

2-Butoxyphenylboronic acid is primarily used in the pharmaceutical industry for the synthesis of boronic acid derivatives used in drug discovery and development. It is also employed in the polymer industry for the preparation of functional polymers and in semiconductor manufacturing as a precursor for boron-containing compounds. Additionally, it has applications in the development of sensors and other advanced materials.

When handling 2-Butoxyphenylboronic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be handled carefully using absorbent materials and disposed of according to local hazardous waste regulations. Always refer to the material safety data sheet (MSDS) for specific safety and handling guidelines.