Baccatin III(CAS: 27548-93-2)

Baccatin III is a natural compound derived from the bark of the European yew tree (Taxus species). It has the chemical formula C21H28O11 and is known for its complex structure, which includes a tetracyclic diterpenoid backbone. Baccatin III is a key intermediate in the synthesis of various anticancer drugs, particularly paclitaxel, and exhibits notable biological activity.

Baccatin III is primarily used in pharmaceutical research and development as a precursor for the synthesis of paclitaxel, a widely used chemotherapy medication. It also finds applications in drug discovery, medicinal chemistry, and as a starting material for the production of other taxane derivatives. Due to its biological properties, it is studied for potential therapeutic uses in cancer treatment and other medical fields.

Baccatin III is generally considered safe when handled properly in controlled laboratory settings. However, as a chemical compound, it requires careful handling to avoid skin contact and inhalation. Safety protocols include the use of personal protective equipment (PPE) such as gloves and goggles. It is important to follow established safety standards to ensure safe use in research and industrial applications.

Baccatin III should be stored in a cool, dry, and dark place, preferably at temperatures below 25°C. It is sensitive to moisture and light, so it should be kept in airtight containers and protected from exposure. Storage in a desiccator or under an inert atmosphere may also be recommended to maintain stability and prevent degradation.