1-Propionyl-4-piperidinecarboxylic acid(CAS: 117705-17-6)

1-Propionyl-4-piperidinecarboxylic acid is a solid compound with a crystalline form. Its molecular weight is approximately 198.28 g/mol. It has low solubility in water but good solubility in organic solvents. Chemically, it is moderately reactive, particularly in esterification reactions. It has a pKa of around 4.5, indicating some acidity.

1-Propionyl-4-piperidinecarboxylic acid is typically synthesized through the condensation of propionyl chloride with 4-piperidinecarboxylic acid. The reaction is usually conducted under anhydrous conditions using a Lewis acid catalyst like aluminum chloride to improve selectivity and yield. The product is then purified by recrystallization or chromatography.

1-Propionyl-4-piperidinecarboxylic acid is used in various industries, including pharmaceuticals for drug synthesis, polymer chemistry for additive production, and sensors for detecting organic compounds. It is also utilized in the synthesis of semiconductors and as a building block in organic synthesis.

When handling 1-Propionyl-4-piperidinecarboxylic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handle the material in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.