6-Bromo-2,3-dihydro-4H-chromen-4-one(CAS: 49660-57-3)

6-Bromo-2,3-dihydro-4H-chromen-4-one is a white crystalline solid with a molecular weight of approximately 247.04 g/mol. It has a solubility of 0.05 g/100 mL in water and is slightly soluble in common organic solvents like ethanol. This compound is known for its low reactivity under normal conditions but can undergo electrophilic aromatic substitution reactions. It is thermally stable and does not decompose readily under normal conditions.

6-Bromo-2,3-dihydro-4H-chromen-4-one is typically synthesized through bromination of 2,3-dihydro-4H-chromen-4-one. This process often involves the use of N-bromosuccinimide (NBS) as a brominating agent in the presence of a suitable oxidant such as azobisisobutyronitrile (AIBN). The yield is around 75-85% and the product is highly selective for the bromination site.

6-Bromo-2,3-dihydro-4H-chromen-4-one is primarily used in pharmaceuticals and as an intermediate in the synthesis of other chromone derivatives. It is also utilized in the development of sensors and materials for their unique optical and electronic properties, making it relevant to the semiconductor industry as well.

When handling 6-Bromo-2,3-dihydro-4H-chromen-4-one, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation. In case of a spill, absorb excess material with paper towels and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for specific handling guidelines and emergency procedures.