1-(4-Methylphenyl)-2-(4-pyridinyl)ethanone(CAS: 100866-13-5)

1-(4-Methylphenyl)-2-(4-pyridinyl)ethanone (CAS: 100866-13-5) is a white crystalline solid with a molecular weight of approximately 237.22 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, showing basic properties due to the presence of the pyridinyl group.

1-(4-Methylphenyl)-2-(4-pyridinyl)ethanone (CAS: 100866-13-5) can be synthesized via a multistep reaction involving the coupling of 4-methylphenyl isocyanide and 4-pyridinecarbaldehyde. The reaction proceeds with high selectivity and yields up to 85% under optimized conditions with the use of appropriate catalysts and solvents.

1-(4-Methylphenyl)-2-(4-pyridinyl)ethanone (CAS: 100866-13-5) is primarily used in the pharmaceutical industry as an intermediate for drug synthesis. It also finds applications in the development of sensors and as a precursor in polymer synthesis for specific industrial applications.

When handling 1-(4-Methylphenyl)-2-(4-pyridinyl)ethanone (CAS: 100866-13-5), ensure the use of personal protective equipment such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation. Store the compound in a cool, dry place away from direct sunlight. In the event of a spill, immediately clean up with appropriate absorbents and dispose of according to local regulations. Refer to the safety data sheet (SDS) for detailed information.