Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate(CAS: 926663-00-5)

Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate is a crystalline solid with a molecular weight of approximately 250.26 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetonitrile. The compound is chemically reactive, particularly towards nucleophiles and bases, making it susceptible to hydrolysis and deamination under basic conditions.

Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate is typically synthesized through a multi-step reaction involving pyrazolo[1,5-a]pyrimidine-3-carboxylic acid and ethyl bromide. The key steps include alkylation followed by carboxylation, catalyzed by sodium hydride or similar strong bases. The overall yield is moderate, ranging from 50% to 70% depending on the purity of starting materials and reaction conditions.

Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It also finds applications in the polymer industry for developing functional polymers and in the sensor industry for its potential use in chemical detection mechanisms. Additionally, it can be used in semiconductor manufacturing for specific chemical processes.

When handling Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be immediately cleaned up with appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and handling guidelines.