N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine(CAS: 116861-26-8)

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine is a colorless or white crystalline solid with a molecular weight of approximately 468.47 g/mol. It is sparingly soluble in water but more soluble in organic solvents. Chemically, it is stable under normal conditions but can react with strong bases. It exhibits significant reactivity in esterification and amide formation reactions.

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine is synthesized via a multi-step process involving the coupling of fluorenylmethanol with serine. The reaction typically uses a catalyst such as N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The yield is generally around 70-80%, and the method provides good selectivity.

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine is primarily used in pharmaceuticals for the synthesis of peptides and proteins. It is also employed in the polymer industry for functionalization and in sensor technology due to its fluorescence properties. Its applications in semiconductors are less common but can be found in specialized research and development settings.

When handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight. Use a fume hood during preparation to minimize inhalation. In case of spill, contain the spill with absorbent material, and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.