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2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine(CAS: 1481677-78-4)
CAS Number
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Other Suppliers for 2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine
Basic Information
Molecular Formula
C29H44F2N6O2
Molecular Weight
546.71 g/mol
Physical Properties
Boiling Point
679.2±65.0°C at 760 mmHg
Chemical Identifiers
SMILES
CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F
InChIKey
RNAMYOYQYRYFQY-UHFFFAOYSA-N
Database References
MDL Number
MFCD28044322
FAQ
2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine is a crystalline compound with a molecular weight of approximately 600.6 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and dimethylformamide. It is moderately reactive, particularly towards nucleophiles. The compound is stable under normal conditions but should be handled with care due to its reactivity.
2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine is synthesized via a multi-step process involving the condensation of 4-(3-pyrrolidin-1-ylpropoxy)-7-(1-propan-2-ylpiperidin-4-yl)quinazolin-2(3H)-one with 1-(4,4-difluoropiperidin-1-yl)ethanamine. The reaction is catalyzed by a phosphine ligand, and the yield is approximately 75%. The product is then purified by recrystallization from a suitable solvent.
2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine is primarily used in the pharmaceutical industry for its potential as an antipsychotic and antidepressant. It is also of interest in the polymer industry for its potential use as a monomer. Additionally, it may have applications in the development of sensors and semiconductors due to its chemical structure.
When handling 2-(4,4-difluoropiperidin-1-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine, it is important to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up immediately with appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.
Safety Notice
Please verify product specifications and safety data before use. Contact the supplier for detailed safety information.
Always follow proper handling procedures
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