N-(5-Amino-2-pyridinyl)-4-(trifluoromethyl)benzamide(CAS: 1011244-68-0)

N-(5-Amino-2-pyridinyl)-4-(trifluoromethyl)benzamide is a white or off-white crystalline solid. Its molecular weight is approximately 356.2 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and acetonitrile. Chemically, it is relatively stable but can undergo hydrolysis under basic conditions. It is also sensitive to light and should be stored in a cool, dark place.

N-(5-Amino-2-pyridinyl)-4-(trifluoromethyl)benzamide can be synthesized by reacting 4-(trifluoromethyl)benzoic acid with 5-aminopyridine in the presence of a coupling agent like HATU (O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate) and a base such as DIPEA (N,N-Diisopropylethylamine). The reaction typically proceeds in an organic solvent like N,N-Dimethylformamide (DMF) at room temperature. The product has a yield of around 70-80%.

N-(5-Amino-2-pyridinyl)-4-(trifluoromethyl)benzamide is primarily used in the pharmaceutical industry as an intermediate for drug synthesis. It is also utilized in the polymer and sensor industries due to its unique chemical properties, such as its ability to form stable complexes and its high reactivity with certain functional groups.

When handling N-(5-Amino-2-pyridinyl)-4-(trifluoromethyl)benzamide, it is important to use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. The compound should be stored in a cool, well-ventilated area away from light and heat. If a spill occurs, it should be handled using appropriate spill cleanup procedures. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.