(3aR,6aS)-3,3a,6,6a-Tetrahydro-2H-cyclopenta[b]furan-2-one(CAS: 43119-28-4)

(3aR,6aS)-3,3a,6,6a-Tetrahydro-2H-cyclopenta[b]furan-2-one is a white solid with a molecular weight of approximately 120.17 g/mol. It has a low solubility in water but is soluble in organic solvents. This compound is chemically stable but can react with strong bases. It is prone to hydrolysis. It is used in the pharmaceutical industry as an intermediate in drug synthesis.

(3aR,6aS)-3,3a,6,6a-Tetrahydro-2H-cyclopenta[b]furan-2-one can be synthesized via a condensation reaction of acetophenone and hexahydro-2H-pyran. Common synthetic methods involve the use of a Lewis acid catalyst such as aluminum chloride. The reaction yields the compound with high selectivity, producing high purity products.

(3aR,6aS)-3,3a,6,6a-Tetrahydro-2H-cyclopenta[b]furan-2-one is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drug compounds. It is also utilized in the polymer industry for producing novel materials and in the sensor industry for developing chemical sensors and detectors.

When handling (3aR,6aS)-3,3a,6,6a-Tetrahydro-2H-cyclopenta[b]furan-2-one, it is essential to use personal protective equipment (PPE) such as gloves and safety goggles. Work in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.