1-(4-Chlorophenyl)-1-propanone(CAS: 6285-05-8)

1-(4-Chlorophenyl)-1-propanone is a colorless to light yellow liquid with a molecular weight of approximately 168.17 g/mol. It has a pKa of around 4.2 and is slightly soluble in water but readily soluble in organic solvents like ethanol and acetone. Chemically, it is less reactive than some ketones due to the electron-withdrawing chlorine substituent, which decreases its reactivity in nucleophilic addition reactions.

1-(4-Chlorophenyl)-1-propanone can be synthesized via the Friedel-Crafts acylation of 4-chlorophenol with acetic anhydride in the presence of Lewis acids like aluminum chloride. The reaction is carried out at elevated temperatures, typically around 100°C, to ensure high yield and selectivity.

1-(4-Chlorophenyl)-1-propanone is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry as a monomer, and in the production of sensors and semiconductors due to its functional groups that can be used in various chemical reactions.

Proper protective equipment such as gloves, goggles, and a lab coat should be worn when handling 1-(4-Chlorophenyl)-1-propanone. It should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and the area should be properly ventilated. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information.