1-(4-Pyridinyl)-1-propanone(CAS: 1701-69-5)

1-(4-Pyridinyl)-1-propanone is a colorless liquid with a molecular weight of approximately 135.16 g/mol. It has a solubility of about 13.6 g/100 mL in water and is soluble in most organic solvents. Chemically, it is moderately reactive, forming stable complexes with transition metal salts and is used as a ligand in coordination chemistry. It is also known for its use in spectroscopy due to its characteristic UV-Vis absorption peaks.

1-(4-Pyridinyl)-1-propanone can be synthesized via a condensation reaction of 4-pyridinecarboxaldehyde with acetone using a mild base such as sodium acetate. The reaction is typically carried out in an aqueous medium at room temperature, yielding a 70-80% isolated yield. The use of appropriate catalysts can improve selectivity and yield.

1-(4-Pyridinyl)-1-propanone is primarily used in the pharmaceutical and chemical industries. It serves as a precursor in the synthesis of various organic compounds and drugs. Additionally, it is used in polymer synthesis and as a ligand in coordination chemistry. Its application in sensor technology for detecting organic compounds and in semiconductor manufacturing is also noteworthy.

Proper personal protective equipment (PPE) including gloves, goggles, and a lab coat should be worn when handling 1-(4-Pyridinyl)-1-propanone. It should be stored in a fume hood to prevent inhalation. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.