5-Chloro-2-nitrobenzaldehyde(CAS: 6628-86-0)

5-Chloro-2-nitrobenzaldehyde is a yellow crystalline solid with a molecular weight of approximately 213.01 g/mol. It has a pKa of 14 and a density of 1.48 g/cm³. Soluble in ethanol, methanol, and acetone, but poorly soluble in water. It is a moderately reactive compound, particularly with nucleophiles and reducing agents.

5-Chloro-2-nitrobenzaldehyde is commonly synthesized via the nitration of 5-chlorobenzaldehyde followed by reduction of the nitro group. The nitration step uses concentrated nitric acid and sulfuric acid as catalysts. The reduction is typically performed using sodium borohydride or catalytic hydrogenation.

5-Chloro-2-nitrobenzaldehyde is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those with aromatic nitro groups. It is also utilized in the production of dyes and pigments, as well as in the synthesis of complex organic compounds for sensors and semiconductors.

When handling 5-Chloro-2-nitrobenzaldehyde, appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat should be worn. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled using appropriate absorbents and properly disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.