3-Bromo-1H-pyrazolo[3,4-c]pyridine(CAS: 76006-13-8)

3-Bromo-1H-pyrazolo[3,4-c]pyridine is a crystalline solid with a molecular weight of approximately 219.02 g/mol. It has a low solubility in water (0.03 g/100 mL at 25°C) but is more soluble in organic solvents like dichloromethane and ethanol. The compound is moderately reactive and can undergo substitution reactions under appropriate conditions.

3-Bromo-1H-pyrazolo[3,4-c]pyridine is typically synthesized via the bromination of 1H-pyrazolo[3,4-c]pyridine using bromine in the presence of a base like sodium hydroxide or potassium hydroxide. The reaction involves electrophilic aromatic substitution, yielding a high yield of the target compound with good selectivity.

3-Bromo-1H-pyrazolo[3,4-c]pyridine is primarily used in pharmaceutical research for its potential as an intermediate in the synthesis of drug candidates. It also finds applications in the development of sensors and as a precursor in the synthesis of other heterocyclic compounds.

When handling 3-Bromo-1H-pyrazolo[3,4-c]pyridine, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risk. In case of a spill, immediately clean up using appropriate absorbent materials and follow safety data sheet (SDS) guidelines for disposal.