2-Bromo-6-fluoroaniline(CAS: 65896-11-9)

2-Bromo-6-fluoroaniline (CAS: 65896-11-9) is a solid at room temperature, with a molecular weight of approximately 187.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like acetone and ethanol. Chemically, it is less reactive compared to other aromatic amines but can undergo electrophilic aromatic substitution reactions, particularly with bromine. Its low reactivity and high stability make it useful in various synthetic processes.

2-Bromo-6-fluoroaniline (CAS: 65896-11-9) is typically synthesized through a coupling reaction of 6-fluoroaniline with bromine in the presence of a phase transfer catalyst, such as tetrabutylammonium bromide. The reaction proceeds under alkaline conditions to favor the formation of the brominated product. The yield is generally high, and the method provides good selectivity for the desired product.

2-Bromo-6-fluoroaniline (CAS: 65896-11-9) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those that require specific functional groups for further modification. It is also utilized in the polymer industry for the production of advanced polymers with specific properties. Additionally, its use in sensors and semiconductors is explored for its unique chemical properties.

When handling 2-Bromo-6-fluoroaniline (CAS: 65896-11-9), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from incompatible materials such as strong acids and bases. In case of a spill, it should be cleaned up using appropriate procedures and with the assistance of safety professionals. Always refer to the Material Safety Data Sheet (MSDS) for specific handling and disposal information.