1H-Pyrazole-3-carboxylic acid(CAS: 1621-91-6)

1H-Pyrazole-3-carboxylic acid is a white crystalline solid with a molecular weight of approximately 132.13 g/mol. It is slightly soluble in water and ethanol. Chemically, it is a weak acid and can react with bases to form salts. It is also prone to hydrolysis under basic conditions and may undergo ring-opening reactions under certain conditions.

1H-Pyrazole-3-carboxylic acid can be synthesized by the condensation of 3-formylpyrazole with a carboxylic acid anhydride, followed by hydrolysis. Alternatively, it can be prepared by the reaction of pyrazole with a carboxylating agent such as carbon dioxide or a carboxylic acid chloride. The yield and selectivity can be improved using appropriate catalysts and reaction conditions.

1H-Pyrazole-3-carboxylic acid is used in the pharmaceutical industry for the synthesis of certain drugs, as well as in the polymer industry for preparing polyamides and other polymers. It also finds applications in the preparation of sensors and semiconductors due to its electronic properties.

When handling 1H-Pyrazole-3-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be carefully cleaned up using appropriate methods, and the area should be ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information.