5-bromoquinazolin-4-ol(CAS: 147006-47-1)

5-Bromoquinazolin-4-ol (CAS: 147006-47-1) is a white to off-white crystalline solid with a molecular weight of approximately 253.03 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and dimethyl sulfoxide. Chemically, it is relatively stable but can react with strong bases to form deprotonated species. It is used in organic synthesis and pharmaceutical research.

5-Bromoquinazolin-4-ol (CAS: 147006-47-1) can be synthesized via a bromination reaction of quinazolin-4(3H)-one using N-bromosuccinimide (NBS) as the brominating agent in the presence of a radical initiator like azobisisobutyronitrile (AIBN). The reaction is typically carried out in an aqueous-organic solvent mixture, achieving a yield of up to 90%.

5-Bromoquinazolin-4-ol (CAS: 147006-47-1) is primarily used in the pharmaceutical industry for the development of novel drugs. It is also utilized in polymer chemistry for the synthesis of functional polymers with specific properties. Additionally, it has applications in the production of sensors and as a precursor in semiconductor manufacturing.

When handling 5-bromoquinazolin-4-ol (CAS: 147006-47-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and lab coats. The substance should be handled in a well-ventilated area or a fume hood to minimize exposure to vapors. In case of a spill, it should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.