2-Methyl-5-nitro-2H-indazole(CAS: 5228-48-8)

2-Methyl-5-nitro-2H-indazole is a crystalline solid with a molecular weight of approximately 184.12 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is stable but can react with strong reducing agents to form 2-methyl-5-aminomethyl-2H-indazole. It is also acidic due to the nitro group, which can protonate under certain conditions.

2-Methyl-5-nitro-2H-indazole can be synthesized via the nitration of 2-methylindazole using nitric acid and sulfuric acid as the nitrating agent. The reaction is carried out in an aqueous phase under controlled temperature conditions to achieve a yield of around 70-80%. Further purification is often required to obtain the high-purity compound.

2-Methyl-5-nitro-2H-indazole is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It also finds applications in the polymer industry for the preparation of polymeric materials, and in the sensor industry for the development of gas sensors. Additionally, it can be used in the semiconductor industry for the fabrication of certain electronic devices.

When handling 2-Methyl-5-nitro-2H-indazole, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn at all times. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In the case of a spill, immediately clean it up using appropriate absorbent materials and wash the area with water. For more detailed safety information, refer to the Safety Data Sheet (SDS) for the compound.