1-Methyl-1H-imidazole-4,5-dicarboxylic acid(CAS: 19485-38-2)

1-Methyl-1H-imidazole-4,5-dicarboxylic acid is a crystalline solid with a molecular weight of approximately 218.14 g/mol. It has a low solubility in water but excellent solubility in organic solvents. The compound is moderately reactive, particularly in acidic conditions, and can participate in esterification and amide formation reactions.

1-Methyl-1H-imidazole-4,5-dicarboxylic acid can be synthesized by reacting 1-methylimidazole with carbon dioxide in the presence of a suitable catalyst. Common methods include the use of Lewis acids such as aluminum trichloride to promote the carboxylation reaction. The yield is typically around 70-80% with good selectivity.

1-Methyl-1H-imidazole-4,5-dicarboxylic acid is used in the pharmaceutical industry for synthesizing complex molecules and as a building block in organic synthesis. It also finds applications in the polymer industry for modifying polymer properties and in the semiconductor industry as a dopant for organic electronics.

When handling 1-Methyl-1H-imidazole-4,5-dicarboxylic acid, it is crucial to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be handled with appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for specific spill procedures. Proper storage in a cool, dry place away from moisture and heat sources is recommended.