(11beta)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate(CAS: 338-98-7)

(11beta)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate is a crystalline compound with a molecular weight of approximately 472.42 g/mol. It has limited water solubility and is relatively stable under normal conditions. The compound exhibits moderate reactivity towards nucleophiles and can undergo hydrolysis under basic conditions. It is insoluble in water but soluble in organic solvents like ethanol and acetone.

(11beta)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate can be synthesized through a multi-step process involving the reduction of a suitable 17-ketosteroid, followed by fluoroalkylation and acetylation. Commonly used catalysts include palladium-based complexes. The synthesis typically yields up to 80% of the desired product, with good regioselectivity and excellent atom economy.

(11beta)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate is used primarily in the pharmaceutical industry, particularly in the development of hormone-related medications. It may also have applications in research for studying steroid hormone metabolism and biosynthesis. No significant use in polymer production, sensors, or semiconductors has been reported.

When handling (11beta)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated fume hood to avoid inhalation. In case of skin contact, immediately wash the affected area with soap and water. Ingestion is highly unlikely, but if it occurs, seek medical attention. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage guidelines.