2-Bromo-4-nitrophenol(CAS: 5847-59-6)

2-Bromo-4-nitrophenol is a crystalline solid with a molecular weight of approximately 217.01 g/mol. It is poorly soluble in water but has good solubility in organic solvents like ethanol and acetone. Chemically, it is highly reactive, particularly towards nucleophilic substitution and reduction reactions. It is a potent oxidant and should be handled with care due to its reactivity.

2-Bromo-4-nitrophenol is typically synthesized by bromination of 4-nitrophenol using bromine in the presence of a phase transfer catalyst such as benzyltriethylammonium bromide. The reaction is carried out in an organic solvent like acetonitrile. The yield is usually high, and the product can be purified by recrystallization or column chromatography.

2-Bromo-4-nitrophenol is used in the pharmaceutical industry as an intermediate for drug synthesis. It also finds applications in the synthesis of dyes and pigments, as well as in the production of various organic compounds used in the polymer and semiconductor industries. Its use in sensors and catalysis is also reported.

When handling 2-Bromo-4-nitrophenol, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the area should be ventilated properly. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.