3-Hydroxy-2-pyrazinecarboxamide(CAS: 55321-99-8)

3-Hydroxy-2-pyrazinecarboxamide (CAS: 55321-99-8) is a crystalline solid with a molecular weight of approximately 146.13 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol. The compound is known for its moderate reactivity, particularly in nucleophilic substitution reactions and condensation reactions. It has a pKa of about 4.5, which indicates its basicity.

3-Hydroxy-2-pyrazinecarboxamide (CAS: 55321-99-8) can be synthesized via a multi-step process involving the condensation of pyrazinecarboxaldehyde with hydroxyamine. The reaction is conducted in the presence of a strong base such as sodium hydroxide. The yield is typically around 70%, and the reaction is highly selective. The process requires careful control of pH and temperature to maximize yield and purity.

3-Hydroxy-2-pyrazinecarboxamide (CAS: 55321-99-8) is used in the pharmaceutical industry for the synthesis of certain drug compounds. It is also applied in the polymer industry for the modification of polymer properties. Additionally, it has potential applications in the production of sensors and semiconductors due to its unique chemical properties.

When handling 3-Hydroxy-2-pyrazinecarboxamide (CAS: 55321-99-8), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood due to its potential irritancy. In case of a spill, it is recommended to use appropriate absorbent materials and dispose of the waste according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.