2-Chloro-N-[(4,6-dimethoxy-2-pyrimidinyl)carbamoyl]imidazo[1,2-a]pyridine-3-sulfonamide(CAS: 122548-33-8)

2-Chloro-N-[(4,6-dimethoxy-2-pyrimidinyl)carbamoyl]imidazo[1,2-a]pyridine-3-sulfonamide is a crystalline solid with a molecular weight of approximately 433.14 g/mol. It has a low solubility in water but is soluble in organic solvents like dimethyl sulfoxide (DMSO). This compound is reactive, particularly towards nucleophiles, and can undergo hydrolysis under basic conditions. It is stable under normal laboratory conditions but should be stored in a dry, cool place to avoid degradation.

2-Chloro-N-[(4,6-dimethoxy-2-pyrimidinyl)carbamoyl]imidazo[1,2-a]pyridine-3-sulfonamide is typically synthesized via a multi-step process involving the protection and functionalization of the imidazo[1,2-a]pyridine ring, followed by the introduction of the pyrimidine moiety and the sulfonamide group. Key reagents include chlorides, amines, and sulfonic acids. The method often involves the use of coupling agents and base catalysts to ensure optimal yield and selectivity.

2-Chloro-N-[(4,6-dimethoxy-2-pyrimidinyl)carbamoyl]imidazo[1,2-a]pyridine-3-sulfonamide is used in the pharmaceutical industry for its potential as a drug candidate. It may also find applications in the development of sensors and as a precursor in the synthesis of other organic compounds. Its use in the polymer industry and semiconductor manufacturing is less common but could be explored for specific applications requiring unique chemical properties.

When handling 2-Chloro-N-[(4,6-dimethoxy-2-pyrimidinyl)carbamoyl]imidazo[1,2-a]pyridine-3-sulfonamide, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency protocols.