(3-Methoxyphenyl)acetonitrile(CAS: 19924-43-7)

(3-Methoxyphenyl)acetonitrile is a colorless or pale yellow liquid with a molecular weight of approximately 167.17 g/mol. It has a melting point of -51°C, boiling point of 176-177°C, and a solubility of up to 10 g/L in water. It is reactive towards nucleophiles and can undergo nucleophilic substitution reactions. This compound is also soluble in common organic solvents like ethanol, acetone, and dichloromethane.

(3-Methoxyphenyl)acetonitrile can be synthesized via the reaction of 3-methoxyphenyl isothiocyanate with acetonitrile in the presence of a base such as potassium carbonate. The reaction is typically carried out at room temperature and yields a product with 90% to 95% selectivity and up to 85% yield. This method provides a straightforward route to the compound.

(3-Methoxyphenyl)acetonitrile is used in various industries, including pharmaceuticals for intermediate synthesis, sensors for detecting specific chemical species, and polymers for modifying their properties. It is also utilized in the semiconductor industry for etching and cleaning processes. The compound's unique chemical structure makes it valuable in these applications.

When handling (3-Methoxyphenyl)acetonitrile, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. Spills should be handled with appropriate absorbents, and the material safety data sheet (MSDS) should be referenced for specific spill procedures. Avoid contact with skin and eyes, and ensure proper disposal according to local regulations. This compound is flammable and can pose health risks if not handled safely.