Methyl 2-chloro-4-fluorobenzoate(CAS: 85953-29-3)

Methyl 2-chloro-4-fluorobenzoate is a crystalline solid with a molecular weight of approximately 191.01 g/mol. Its solubility is about 3.5 g/L in water and it is slightly soluble in ethanol. This compound is relatively reactive, particularly with nucleophiles. It exhibits high reactivity due to the electrophilic aromatic character of the chloro and fluoro substituents.

Methyl 2-chloro-4-fluorobenzoate is commonly synthesized by the chlorination of methyl benzoate followed by fluorination. The chlorination step is usually performed with thionyl chloride, while the fluorination can be achieved using hydrogen fluoride or fluoroform in the presence of a suitable catalyst such as aluminum fluoride.

Methyl 2-chloro-4-fluorobenzoate finds applications in the pharmaceutical industry for the synthesis of drug intermediates. It is also utilized in polymer synthesis, as a precursor for the production of fluorinated polymers. Additionally, it is used in the development of sensors and semiconductors due to its specific chemical properties.

When handling Methyl 2-chloro-4-fluorobenzoate, it is essential to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. Work should be conducted in a fume hood to minimize exposure. Spills should be carefully managed and cleaned up using appropriate absorbent materials. For detailed safety information, refer to the Material Safety Data Sheet (MSDS/SDS).