4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide(CAS: 71320-77-9)

4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide (CAS: 71320-77-9) is a crystalline solid with a molecular weight of approximately 305.7 g/mol. It is slightly soluble in water and more soluble in organic solvents like DMSO and DMF. The compound exhibits basic reactivity due to the amide group and the morpholine moiety, making it susceptible to acid-catalyzed hydrolysis. It has a pKa around 8.5, indicating a basic nature.

4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide (CAS: 71320-77-9) is typically synthesized by the condensation of 4-chlorobenzoyl chloride with 2-(4-morpholinylethyl)amine. This reaction is catalyzed by a base such as triethylamine. The process yields a product with high selectivity and good yield, approximately 90%, under mild conditions.

4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide (CAS: 71320-77-9) is primarily used in pharmaceuticals for its potential as a drug candidate. It may also find applications in the production of polymers, where its amide functionality can contribute to material properties. Additionally, it can be used in the development of sensors and semiconductors due to its chemical reactivity and structural features.

When handling 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide (CAS: 71320-77-9), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place, away from direct sunlight and sources of heat. Laboratory fume hoods should be used during all handling procedures to minimize exposure. In case of a spill, immediately contain it and follow the safety data sheet (SDS) guidelines for disposal. Ensure proper ventilation in the laboratory at all times.