5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one(CAS: 2798-20-1)

5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one is a crystalline solid with a molecular weight of approximately 436.43 g/mol. It has a solubility of 1.2 g/L in water and is generally insoluble in common organic solvents. This compound is known for its high reactivity towards nucleophiles and electrophiles. It tends to form stable derivatives under certain conditions.

5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one is typically synthesized via a multistep process involving the condensation of 4-methoxyphenol with 2,3,4-trimethoxyacrylonitrile in the presence of a Lewis acid catalyst. The final step involves hydrogenation of the nitrile group to form the chromene ring system, achieving a yield of up to 90%. This process is highly selective and provides good control over product purity.

5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of bioactive compounds. It also finds applications in the production of functional polymers and sensors, where its chromophoric properties are exploited. In the semiconductor industry, it is used as a precursor for the synthesis of organometallic compounds.

When handling 5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one (CAS: 2798-20-1), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for specific cleanup procedures. Storage should be in a cool, dry place away from heat sources and oxidizers.