2-Amino-9-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one(CAS: 85326-06-3)

2-Amino-9-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one is a crystalline solid with a molecular weight of approximately 301.27 g/mol. It is slightly soluble in water but soluble in organic solvents like methanol and ethanol. The compound has moderate reactivity, particularly with acidic and basic conditions, and is prone to hydrolysis. It exhibits good stability in neutral pH solutions and is susceptible to degradation under high temperatures and light exposure.

2-Amino-9-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one can be synthesized through a multi-step process involving the condensation of 2-amino-6-oxopurine and (2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-carbaldehyde. The reaction is carried out in the presence of a catalyst such as palladium acetate. The process yields a high purity product with good selectivity and a yield of approximately 75-80%.

2-Amino-9-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one is primarily used in the pharmaceutical industry as a precursor for drug synthesis. It has also found applications in the development of sensors and semiconductors due to its electronic and optical properties. Additionally, it can be used in the polymer industry for the modification of materials.

When handling 2-Amino-9-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of dust or vapors. Spills should be cleaned up immediately using absorbent material, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.