2,3,6-Trichloro-4-(trifluoromethyl)aniline(CAS: 86399-04-4)

2,3,6-Trichloro-4-(trifluoromethyl)aniline is a crystalline solid with a molecular weight of approximately 314.01 g/mol. It has low water solubility, with a maximum solubility of about 0.03 g/L at 20°C. The compound is known for its high reactivity, particularly towards nucleophiles and electrophiles. It is also unstable at high temperatures and in the presence of moisture.

2,3,6-Trichloro-4-(trifluoromethyl)aniline can be synthesized via the reduction of 2,3,6-trichloro-4-nitroaniline with a suitable reducing agent like sodium borohydride or lithium aluminum hydride. The key synthetic steps involve nitration of aniline followed by chlorination and trifluoromethylation, with careful control of reaction conditions to achieve high yield and selectivity.

2,3,6-Trichloro-4-(trifluoromethyl)aniline is primarily used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients. It also has applications in the polymer industry for the production of special polymers, and in sensors and semiconductors for specific functional materials. Its unique chemical properties make it valuable in these specialized fields.

When handling 2,3,6-Trichloro-4-(trifluoromethyl)aniline, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be thoroughly rinsed. Always refer to the Safety Data Sheet (SDS) for detailed safety instructions and emergency procedures.