2-Iodoisonicotinic acid(CAS: 58481-10-0)

2-Iodoisonicotinic acid is a crystalline solid with a molecular weight of approximately 225.02 g/mol. It has a high solubility in water and poor solubility in organic solvents. The compound is moderately reactive, particularly under acidic conditions, and can undergo substitution reactions. It is stable under normal conditions but may decompose at high temperatures.

2-Iodoisonicotinic acid is typically synthesized by reacting nicotinic acid with iodine in the presence of a suitable catalyst, such as potassium carbonate. The reaction is carried out in a polar aprotic solvent like dimethylformamide (DMF) at room temperature. The yield is usually around 80%, and the product is isolated by crystallization from aqueous solution.

2-Iodoisonicotinic acid is used in various industries, primarily in pharmaceuticals for the synthesis of certain drugs. It also finds application in the preparation of materials for sensors and semiconductors. Its use in polymers is limited but explored for specific functional polymer applications.

When handling 2-Iodoisonicotinic acid, it is crucial to wear appropriate personal protective equipment (PPE), including gloves and goggles. Handle the compound in a well-ventilated area or fume hood to avoid inhalation of its vapors. Spills should be cleaned up with caution, using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed safety information.